Campomelic syndrome is a rare birth defect that affects the development of the bones and muscles. It can affect one or both sides of the body, but it's most often seen in the lower legs. The bones in the lower leg are shorter than normal and often bowed. The foot may also be turned inward. This condition can also cause problems with muscle development and function, including weakness of the thigh muscles, hip joint problems, and knee joint problems.
People who have campomelic syndrome have shorter arms and legs than normal, which can make it hard for them to run or jump. They may also have problems with their hands and feet. Some people with the campomelic syndrome have fingers that are fused together in one or more places, which makes it difficult for them to move their hands.
There are many risk factors for the campomelic syndrome, including:
1. Genetics: You're more likely to have campomelic syndrome if a family member has it. Campomelic syndrome is one of many types of skeletal malformations that can occur as a result of genetic mutation. The exact cause of CAMPOMELIC SYNDROME has not yet been identified, but researchers have found that it tends to run in families—meaning that if you have this condition, your child may also develop it.
2. Race: Campomelic syndrome is more common in people with African or Asian ancestry than in those with white or Hispanic ancestry.
3. Sex: Campomelic syndrome is more common in girls than boys, but both genders can be affected by this condition.
4. Environmental factors: Environmental factors such as radiation exposure, viruses and medications may also increase the risk for the campomelic syndrome.
A short arm and leg (dolichostenomelia),Elbow and knee deformities,Hip dislocation in more than half of patients,Short fingers and toes (brachydactyly),Abnormal spine curvature (kyphosis or lordosis)
Congenital clubfoot,Short Achilles tendon,Short calf muscle,Shortening of the tibia bone,Short femur bone,Abnormal placement of the hip joint,Abnormally short femur bone and abnormal placement of the hip joint
Corticosteroids,Calcium and Vitamin D supplements,Bisphosphonates,Anti-diuretic hormone (ADH) analogues