The most prominent feature of cleidocranial dysplasia is a premature closure of the two soft spots on the head (fontanels) and the fibrous joints where bones of the skull meet (sutures) causing abnormal development of the skull. Facial features typically include a prominent forehead, unusually wide face, prominent chin, small upper jaw (maxillary hypoplasia) and bulging of the skull cap. Narrow drooping shoulders caused by complete or partial absence of collarbones (clavicles) are also apparent in patients with this disorder. There may be abnormalities of the muscles in the area of the collarbones allowing for a wide range of movement of the shoulders.
Other bone abnormalities that have been found in some patients with Cleidocranial dysplasia may be: a wide pelvic joint, delayed growth of the pubic bone, a hip defect in which the thigh bone angles towards the center of the body (coxa vara), failure of the lower jaw bones to unite, a defect of the hip that causes the thigh bone to angle out to the side of the body (coxa valga), curvature of the spine (scoliosis), a small shoulder blade, and/or curvature of the upper legs so that the knees appear unusually close together (genu valgum).
Dental abnormalities may include: a delay in tooth eruption, incomplete development or absence of teeth, underdeveloped enamel and/or extra teeth. Cysts may form around the unerupted or displaced teeth in some cases. A high-arch palate or a condition in which there is a hole in the roof of the mouth (cleft palate) may be present.
Individuals with cleidocranial dysplasia have an increased risk for recurrent ear and sinus infections, upper respiratory complications and hearing loss.