Granulocytopenia primary, also known as agranulocytosis, is an immunological disorder, in which granulocyte count in the blood reduces below the normal range. Granulocytes are a family of immune cells known as white blood cells (WBCs).
1. When a person is diagnosed with the disease, any suspected medications or offending agents must be stopped.
2. In immunocompromised persons, general care, such as oral hygiene, to control infections is important. Skin infections and abrasions are to be treated immediately and promptly.
3. Immune cells are products of a series of processes that occur in the bone marrow. These processes are initiated by various hematopoietic growth factors. Such factors are prescribed to accelerate production. They include Filgrastim, a granulocyte colony-stimulating factor (G-CSF), Sargramostim, a granulocyte-macrophage colony-stimulating factor, and Pegfilgrastim, a long-acting filgrastim.
4. In case of infections, antibiotics are the choice of treatment as follows:
-Third-generation cephalosporins or equivalents
-Cefepime, carbapenems (e.g., meropenem, imipenem-cilastatin), or piperacillin-tazobactam
-Vancomycin or linezolid in case of methicillin-resistant Staphylococcus aureus.
-Linezolid or daptomycin in cases of vancomycin-resistant enterococcus
-Carbapenems against extended-spectrum beta-lactamase (ESBL) producing gram-negative bacteria.
-Antifungal agents include amphotericin B (preferably lipid formulation), a broad-spectrum azole (e.g., voriconazole), or an echinocandin (e.g., caspofungin).
The initial symptoms are often malaise, fever, and chills, or infections, which usually present in the form of ulcers, necrotizing lesions of the gingiva, the floor of the mouth, buccal mucosa, pharynx, or other sites within the oral cavity,Pharyngitis, with difficulty in swallowing and multiple skin abscesses, could be another presentation of the disease
Neutropenia (lower-than-normal levels of white blood cells and are very vulnerable to infection),Immunodeficiency
Hematopoietic growth factors include injections like Filgrastim, Sargramostim, and Pegfilgrastim,Third-generation cephalosporins or equivalents
Cefepime, carbapenems (e.g., meropenem, imipenem-cilastatin), or piperacillin-tazobactam, Vancomycin, linezolid or daptomycin,Carbapenems
Antifungal agents include amphotericin B (preferably lipid formulation), a broad-spectrum azole (e.g., voriconazole), or an echinocandin (e.g., caspofungin)