The exact cause of Kohler disease is unknown. It may be genetic, but it could also be caused by a viral infection or exposure to certain medications. The condition can affect multiple parts of the body, including the skull and jawbones.
Kohler's disease is characterized by thick, rough skin that peels easily, leading to pain and inflammation. The skin may be discolored and feel bumpy. The hair on the scalp may become coarse and brittle, and the scalp itself may become inflamed and cracked.
The condition is most common in males between the ages of 30 and 60, but it can occur at any age. In some cases, it affects one side of the body only; others have both sides affected equally.
Doctors usually diagnose Kohler disease during childhood after noticing abnormalities in bone density during an x-ray or MRI scan of the head region.
Risk factors for Kohler disease include:
1. Genetic mutations
2. Having another kidney disease like focal segmental glomerulosclerosis or Alport syndrome
3. Being born with a birth defect of the kidneys, bladder or urethra
4. Sex: Boys have a higher risk of developing Kohler disease than girls.
5. Family history: A family history of Kohler disease increases your risk of developing it.
Pain in the feet and ankles,Swelling of the feet and ankles,Tingling or numbness in the feet and ankles,Cold hands and feet, even when it's warm outside,A burning sensation in the hands and feet,Fatigue or weakness in arms or legs
Hemolytic anemia due to paroxysmal cold hemoglobinuria,Sickle cell anemia,Thalassemia major,Hemolytic crisis, for example in spherocytosis and disseminated intravascular coagulation (DIC),Von Gierke disease (Type II glycogen storage disease; glucose 6-phosphate deficiency)
Digoxin,ACE inhibitors,Aldosterone antagonists