Multi-Synostotic osteo dysgenesis (MSOD) is a rare skeletal disease that causes multiple areas of abnormal bone growth and development. The bones affected by MSOD are usually the long bones in the arms or legs, such as the femur, humerus, ulna, or radius.
In people with MSOD, abnormal bone growth occurs during childhood and adolescence. Children with this condition often experience pain in their joints and bones. They may also have short stature because of abnormal bone growth in their limbs.
The most common symptoms include:
1. Short stature (a child who is significantly shorter than average for his/her age)
2. Osteopenia (low bone mineral density)
3. Fractures or breaks in bones that occur even with normal activity
4. Increased risk of developing cancerous cells within bones
The cause of MSOD is unknown. It is not known how the disease is passed from one generation to another, but it appears to be inherited in an autosomal dominant pattern (with one defective gene being passed from a parent).
Risk factors for multi-synostotic osteo dysgenesis include:
1. Hereditary conditions, such as Bloom's syndrome and Gardner's syndrome
2. Radiation therapy to the head or neck
3. Genetic syndromes, like Down syndrome and Turner's syndrome.
4. Family history of the condition.
5. Prematurity, low birth weight, and small size at birth.
6. A history of prematurity and low birth weight increases the risk of developing multi-synostotic osteo dysgenesis in later life by about 40%.
A lump on the head or face,Severe pain throughout the body,Seizures,Loss of vision
Hypophosphatasia,Albright hereditary osteodystrophy,Ollier's disease,Fibrous dysplasia,Multiple exostoses
Sodium fluoride,Fluoride varnish,Amoxicillin,Calcium carbonate,Calcium lactate,Calcium gluconate