The treatment of Catel-Manzke syndrome is directed toward the specific symptoms that are apparent in each individual. Treatment may require the coordinated efforts of a team of specialists. Pediatricians, orthopedists, craniofacial surgeons, cardiologists, speech therapists, and other healthcare professionals may need to systematically and comprehensively plan an affect child’s treatment. Genetic counseling may be of benefit for affected individuals and their families. Psychosocial support for the entire family is essential as well.
There are no standardized treatment protocols or guidelines for affected individuals. Due to the rarity of the disease, there are no treatment trials that have been tested on a large group of patients. Various treatments have been reported in the medical literature as part of single case reports or small series of patients. Treatment trials would be very helpful to determine the long-term safety and effectiveness of specific medications and treatments for individuals with Catel-Manzke syndrome.
Specific therapies for the treatment of Catel-Manzke syndrome are symptomatic and supportive. For infants with feeding and respiratory difficulties recommended disease management may include keeping infants on their stomachs (prone positioning) and monitoring of breathing. In some cases, treatment may also require placement of a breathing tube or, if necessary, the performance of certain surgical procedures. Such measures may include a procedure in which the tongue is temporarily joined to the lower lip (tongue-lip adhesion) to keep the tongue from blocking the airway or creation of an opening through the neck into the windpipe into which a tube is inserted (tracheostomy).
In addition, surgical measures to correct cleft palate will be advised at the appropriate age during infancy or childhood in order to repair the abnormality and to help improve speech development. Physicians may also recommend surgical correction of additional, associated craniofacial malformations in some cases.
In some cases, physicians may advise surgical repair or correction of finger (digital) malformations, additional skeletal defects, and/or other abnormalities associated with the syndrome.
For infants and children with congenital heart defects, treatment with certain medications, surgical intervention, and/or other measures may also be required. The specific surgical procedures performed will depend upon the size, nature, severity, and/or combination of the anatomical abnormalities, their associated symptoms, and other factors.
Early intervention may also be important in ensuring that affected children reach their potential. Special services that may be beneficial include special education, speech therapy, physical therapy, and/or other medical, social, and/or vocational services.