About marfanoid hypermobility syndrome

What is marfanoid hypermobility syndrome?

Marfan syndrome is a genetic disorder that affects connective tissue, which is the material between cells of the body that gives the tissues form and strength. Connective tissue is found all over the body and multiple organ systems may be affected in individuals with Marfan syndrome. The heart and blood vessels (cardiovascular), skeletal, and eye (ocular) systems are most often affected. Major symptoms include overgrowth of the long bones of the arms and legs, abnormal side-to-side curvature of the spine (scoliosis), indentation or protrusion of the chest wall (pectus), dislocation of the lenses of the eyes (ectopia lentis), nearsightedness (myopia), widening (aneurysm) and tear (dissection) of the main artery that carries blood away from the heart (aorta), floppiness of the mitral valve (mitral valve prolapse) and backward flow of blood through the aortic and mitral valves (aortic and mitral regurgitation). The specific symptoms and the severity of Marfan syndrome vary greatly from case to case. Marfan syndrome is inherited as an autosomal dominant trait. Defects or disruptions (mutations) of the fibrillin-1 (FBN1) gene have been linked to Marfan syndrome and related disorders.

What are the symptoms for marfanoid hypermobility syndrome?

Bones overgrowth symptom was found in the marfanoid hypermobility syndrome condition

Marfanoid Hypermobility syndrome is a genetic condition that affects the connective tissue in the body. In many ways, it resembles the more common Marfan syndrome. However, while Marfan syndrome is a rare genetic disorder that can cause serious health problems and even death, marfanoid Hypermobility syndrome is much less severe—it's estimated that fewer than 1% of people with Marfan syndrome actually have this condition.

1. The most common symptoms include joint pain, loose joints, and stretchy skin (like bungee jumping). If you have marfanoid Hypermobility syndrome, your joints may be very flexible and stretchy; if you're really lucky, your fingers may touch your thumb.

2. People with MHS are more flexible than average, which can make them seem like they're "double-jointed." They often have long arms, legs, fingers, and toes, as well as flat feet. Some people also have Scoliosis (curved spine), pectus excavatum (sunken chest), high blood pressure, and heart murmurs.

3. The most common cause of death in adults with MHS is aortic dissection—a tear in the wall of the main artery leading from your heart to your body. This tear can cause blood clots to form inside the artery or break off and travel through your bloodstream until they block another artery in your heart, brain, or lungs.

4. The most common signs and symptoms of marfanoid Hypermobility syndrome include joint pain, particularly in your knees and elbows, inability to fully straighten your fingers, toes, or neck, and a big toe that points inward or upward (called "pes planus") and flat feet.

Symptoms
Joint Pain that affects your hands, feet, knees, elbows, wrists, shoulders or hips,Muscle Pain that affects your legs or back,Dislocation of joints like the knee or shoulder
Conditions
Loose joints that are easily stretched out beyond their normal range of motion,Ligaments in the knees and ankles being stretched out beyond their normal range of motion,Tight hamstrings,Tight muscles in general (which makes it hard to stretch out),Scoliosis or curvature of the spine (a sideways S shape)
Drugs
Anti-inflammatory Medication: Ibuprofen (Advil), Naproxen (Aleve),Muscle Relaxants: Cyclobenzaprine (Flexeril),Antidepressants: Tricyclic antidepressants,Antipsychotics: Aripiprazole (Abilify)

What are the causes for marfanoid hypermobility syndrome?

Marfanoid hypermobility syndrome (MHS) is a condition that affects connective tissue, which is the stuff in your body that holds you together. The most well-known connective tissues are cartilage and bone, but MHS also affects ligaments, tendons, and other tissues.

Connective tissues are affected by MHS because they're made of a protein called fibrillin-1. When this protein isn't working right, it can cause joint problems like dislocated shoulders and knees that slip out of place easily. It can also cause swelling in the hands and feet, chest pain, and breathing problems.

There are a number of factors that can contribute to Marfanoid hypermobility syndrome, including:

1. Genetics: Marfanoid hypermobility syndrome is caused by a genetic mutation. People with this condition have a mutation in the FBN1 gene, which causes them to produce less of a protein called fibrillin-1. Fibrillin-1 is needed for strong connective tissue and helps control cell growth and movement. When there's not enough fibrillin-1, the body doesn't form strong connective tissue as it should. This can lead to weak joints and bones, which are common symptoms of marfanoid hypermobility syndrome.

2. Aging: As you get older, your bones start to lose calcium and become weaker. The same thing happens with your connective tissue—it loses strength as you age. This can lead to joint problems like osteoarthritis or degenerative changes in your spine or knees that make it harder for you to move around easily or walk long distances comfortably.

3. Having a family history of diabetes

4. Being diagnosed with another connective tissue disease like Ehlers-Danlos Syndrome (EDS) or Loeys-Dietz Syndrome (LDS).

5. Loeys-Dietz syndrome

6. Ehlers-Danlos syndrome type 3 (hypermobility type)

7. Marfan disease

Symptoms
Joint pain that affects your hands, feet, knees, elbows, wrists, shoulders or hips,Muscle pain that affects your legs or back,Dislocation of joints like the knee or shoulder
Conditions
Loose joints that are easily stretched out beyond their normal range of motion,Ligaments in the knees and ankles being stretched out beyond their normal range of motion,Tight hamstrings,Tight muscles in general (which makes it hard to stretch out),Scoliosis or curvature of the spine (a sideways S shape)
Drugs
Anti-inflammatory Medication: Ibuprofen (Advil), Naproxen (Aleve),Muscle Relaxants: Cyclobenzaprine (Flexeril),Antidepressants: Tricyclic antidepressants,Antipsychotics: Aripiprazole (Abilify)

What are the treatments for marfanoid hypermobility syndrome?

Treatment methods for Marfanoid Hypermobility Syndrome include:

1. Physical Therapy: The main treatment method for Marfanoid Hypermobility Syndrome is physical therapy. Physical therapists help patients manage the pain, loosen tight muscles and ligaments, and improve their range of motion.

2. Medications: Medications can be used to reduce pain. They can also be used to treat symptoms such as high blood pressure, which may occur in some people with Marfanoid Hypermobility Syndrome.

Some of the medications include:

1. Calcium channel blockers like Nifedipine and Verapamil are used to treat the increased blood pressure that comes with Marfanoid Hypermobility Syndrome. These medications work by slowing down your heart rate, which can help reduce your blood pressure.

2. Beta-blockers are used to treat the problems associated with Marfanoid Hypermobility Syndrome that can result from high blood pressure, including chest pain and heart palpitations. These medications work by reducing the amount of adrenaline in your body, which helps lower your blood pressure and decrease the symptoms of high blood pressure.

3. ACE inhibitors are used to treat an aortic aneurysm in people with Marfanoid Hypermobility Syndrome by reducing the amount of protein your kidneys make in order to keep your body from being damaged by high levels of protein in your urine or bloodstream (proteinuria).

4. Surgery: If you have severe joint instability or other complications from Marfanoid Hypermobility Syndrome, surgery may be an option for you. Surgery may also be needed if your joints are damaged from repeated stress or injury.

Symptoms
Joint pain that affects your hands, feet, knees, elbows, wrists, shoulders or hips,Muscle pain that affects your legs or back,Dislocation of joints like the knee or shoulder
Conditions
Loose joints that are easily stretched out beyond their normal range of motion,Ligaments in the knees and ankles being stretched out beyond their normal range of motion,Tight hamstrings,Tight muscles in general (which makes it hard to stretch out),Scoliosis or curvature of the spine (a sideways S shape)
Drugs
Anti-inflammatory Medication: Ibuprofen (Advil), Naproxen (Aleve),Muscle Relaxants: Cyclobenzaprine (Flexeril),Antidepressants: Tricyclic antidepressants,Antipsychotics: Aripiprazole (Abilify)

What are the risk factors for marfanoid hypermobility syndrome?

If you're wondering what marfanoid hypermobility syndrome is, it's important to know that it's not an actual disease. So, what is marfanoid hypermobility syndrome? It's a term that describes a group of disorders that all have similar symptoms.

Marfanoid hypermobility syndrome is actually a group of connective tissue disorders that cause the joints in your body to be loose and flexible—much more so than normal. This means that they're more likely to dislocate or sustain damage during strenuous activity or in response to stress. The reason for this looseness is that the ligaments and tendons are too elastic.

The risk factors of Marfanoid Hypermobility Syndrome include:

1. Age. Marfanoid hypermobility syndrome typically begins to show when a child is around 4 or 5 years old, though it can sometimes be diagnosed as late as age 15 or 16.

2. Gender. More than 90 percent of people with marfanoid hypermobility syndrome are female. It's unknown why this is the case, but it may have something to do with hormones and/or genetics.

3. Family history of MHS. If one parent has MHS and passes on their genes, there's an 80 percent chance that their child will have MHS as well—though this doesn't mean they'll necessarily develop all of its symptoms.

Symptoms
Joint pain that affects your hands, feet, knees, elbows, wrists, shoulders or hips,Muscle pain that affects your legs or back,Dislocation of joints like the knee or shoulder
Conditions
Loose joints that are easily stretched out beyond their normal range of motion,Ligaments in the knees and ankles being stretched out beyond their normal range of motion,Tight hamstrings,Tight muscles in general (which makes it hard to stretch out),Scoliosis or curvature of the spine (a sideways S shape)
Drugs
Anti-inflammatory Medication: Ibuprofen (Advil), Naproxen (Aleve),Muscle Relaxants: Cyclobenzaprine (Flexeril),Antidepressants: Tricyclic antidepressants,Antipsychotics: Aripiprazole (Abilify)

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